Table 5. Multivariate analyses of factors associated with treatment response and liver resection.
|
Treatment response (CR, PR)
|
Liver resection
|
|||||
|---|---|---|---|---|---|---|
| Characteristics | OR | 95% CI | P-value | OR | 95% CI | P-value |
| Age (years) | 1.1 | 0.9–1.2 | 0.105 | 1.1 | 0.9–1.3 | 0.080 |
| Sex | ||||||
| Male | ||||||
| Female | 1.0 | 0.2–4.8 | 0.963 | 1.8 | 0.4–9.0 | 0.434 |
| Primary tumour location | ||||||
| Rectum | ||||||
| Colon | 1.7 | 0.5–6.5 | 0.409 | 1.4 | 0.3–5.7 | 0.635 |
| Distant metastasis | ||||||
| Liver and lung | ||||||
| Liver only | 2.3 | 0.2–21.8 | 0.473 | 1.5 | 0.1–19.3 | 0.757 |
| Number of liver lesions | 1.4 | 1.1–1.8 | 0.010 | 1.2 | 0.9–1.4 | 0.056 |
| Size of liver lesions (cm) | 1.0 | 0.9–1.0 | 0.159 | 0.9 | 0.9–1.0 | 0.167 |
| Location of liver lesions | ||||||
| Bilobe | ||||||
| Unilobe | 1.4 | 0.3–7.4 | 0.691 | 1.2 | 0.2–7.9 | 0.812 |
| Pretreatme CEA (ng ml−1) | 1.0 | 0.9–1.0 | 0.605 | 0.9 | 0.9–1.0 | 0.376 |
| Chemotherapy regimen | ||||||
| FOLFOX | ||||||
| FOLFIRI | 3.3 | 0.8–14.3 | 0.113 | 1.3 | 0.2–6.8 | 0.751 |
| ATP-CRA | ||||||
| No | ||||||
| Yes | 15.2 | 2.4–96.3 | 0.004 | 16.8 | 2.0–139.6 | 0.009 |
Abbreviations: ATP-CRA=adenosine triphosphate-chemotherapy response assay; CEA=carcinoembryonic antigen; CI=confidence interval; CR=complete response; OR=odds ratio; PR=partial response; Size, the sum of the longest diameter of liver metastases.