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. 2011 Nov 24;106(1):107–115. doi: 10.1038/bjc.2011.495

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Copyright © 2012 Cancer Research UK

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Vorinostat (vo) induces SCC cancer selective cytotoxicity. SCC cell lines (SCC25, Cal27, SCC9) and HKs were treated with varying concentrations of vofor 24 h. (A) BrdU incorporation and (B) cytotoxicity for three different HNSCC cell lines and HKs were determined as described in the text. Values are means±s.e. of two independent experiments performed in triplicate. (C, D) SCC25 cells were treated with vo (5 μM) for 24 h and the LDH release (C) or PI staining (D) calculated as a percent of total. ^***Indicates P⩽0.001 vs control (CTR). Values are mean±s.e.m. of at least three experiments performed in triplicate.