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. 2011 Nov 22;106(1):18–24. doi: 10.1038/bjc.2011.498

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Copyright © 2012 Cancer Research UK

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(A) Top 1 cleavage complexes are ordinarily removed through TDP1- and PARP-dependent mechanisms, with the ssDNA breaks repaired through XRCC1 and DNA through polymerases/ligases. (B) Camptothecin (and irinotecan via SN38) stabilises the cleavage complexes, with the persistent ssDNA breaks converting to dsDNA lesions causing cell death, and expected synergy with TDP1/PARP inhibition.