Table 2. Toxicities possibly, probably, and definitely related to treatment.
| Dacarb/dasatinib | Grade | Heme | GI | Resp. | Integ. | Pain | Constit. | Lab | Other |
|---|---|---|---|---|---|---|---|---|---|
| 800/50 b.i.d. | 1 and 2 | Neutro (1) Anaemia (2) Platelets (1) | Nausea (2) Diarrhoea (2) Anorexia (2) Dehydr (1) Constip (1) | Alopecia (1) | Headache (2) | Fatigue (2) | Low alb (2) Low Na (1) Low Ca (1) | Dizziness (1) | |
| 3 and 4 | |||||||||
| 800/70 b.i.d. | 1 and 2 | Neutro (4) Anaemia (14) Platelets (11) | Anorexia (3) Diarrhoea (8) Nausea (13) Constip (5) Dysphagia (1) Dysgeusia (1) Anorexia (2) Mucositis (1) | Effusion (1) Dyspnea (2) Oedema (1) | Rash (7) Alopecia (2) Flushing (3) | Headache (8) Abdomen (1) Myalgias (1) Face (1) Hand (1) | Fatigue (10) Sweats (2) Chills (3) Insomnia (2) Wt loss (1) Fever (4) | High Mg (2) Low Mg (2) Low Ca (1) High gluc (2) Alk phos (5) ALT (5) AST (1) Low alb (2) | Anxiety (1) Oedema (5) Numbness (2) HSR (2) Depress (1) Polyuria (1) Dizziness (1) Neuropathy (1) |
| 3 and 4 | Neutro (6) Anaemia (3) Platelets (3) | Dyspnea (1) | High gluc (1) Low Na (1) | ||||||
| 1000/70 b.i.d. | 1 and 2 | Neutro (2) Anaemia (6) Platelets (4) | Nausea (11) Diarrhoea (7) Er satiety (1) Constip (1) Anorexia (3) Mucositis (1) Tongue sw (1) | Effusions (3) Atelect (1) Cough (1) Hiccups (1) Dyspnea (1) | Rash (5) Alopecia (3) Pruritis (3) Flushing (1) Dry skin (1) | Foot (1) Headache (4) Myalgias (1) Abdomen (2) | Fatigue (4) Chills (2) Fever (3) Insomnia (1) | Low Ca (1) Low K (1) AST (1) High gluc (1) | Long QT (5) Tachycard (1) Orthostasis (1) Ging bleed (1) Oedema (1) |
| 3 and 4 | Neutro (4) Anaemia (4) Platelets (7) | Diarrhoea (1) | Oedema (1) | Low Na (1) | MI (1) Neu fever (2) | ||||
| 1000/140 daily | 1 and 2 | Anaemia (3) Platelets (2) | Dry mouth (1) Nausea (2) Constip (1) Abd dist (1) Anorexia (1) Diarrhea (1) | Effusion (2) | Rash (1) | Headache (1) Dysaesthesia (1) | Fatigue (3) Chills (2) Hot flash (1) Wt loss (1) Insomnia (1) Sweats (1) | Alk phos (1) Low Na (1) | Long QT (1) Oedema (1) Weakness (1) |
| 3 and 4 | Neutro (1) Platelets (1) | Dyspnea (2) | |||||||
| 1000/100 daily | 1 and 2 | Neutro (2) Anaemia (3) Platelets (3) | Nausea (6) Anorexia (2) Diarrhoea (2) | Dyspnea (1) Cough (1) Effusion (1) | Rash (4) | Headache (2) Abdomen (1) | Fatigue (6) Fever (1) Chills (1) | Alk phos (1) ALT (2) AST (1) | Epistaxis (1) Oedema (2) |
| 3 and 4 | Neutro (5) Platelets (1) | Fatigue (1) | GI bleed (1) |
Abbreviations: Abd dist=abdominal distention; Alb=albumin; Alk phos=alkaline phosphatase; ALT=alanine aminotransferase; AST=aspartate aminotransferase; Constip=constipation; Constit.=constitutional; Dehydr=dehydration; GI=gastrointestinal; gluc=glucose; HSR=hypersensitivity reaction; Integ.=integument; MI=myocardial infarction; Neutro=neutropenia; QT=QT interval in the electrocardiogram; Resp.=respiratory; Tongue sw=tongue swelling; Wt=weight.
Only the highest-grade toxicity for each patient is reported. Grade 3 and 4 toxicities are noted in shaded regions. The number of events is in parentheses.