Table 1. Characteristics of women included in this analysis, and of follow-up, by selected reproductive factor categories.
All women |
Age at menarche
|
Age at menopausea
|
Parity
|
||||
---|---|---|---|---|---|---|---|
Number of women | 1 319 409 | ⩽13 Years 806 948 | 14+ Years 485 230 | <50 Years 168 875 | 50+ Years 236 050 | Nulliparous 142 622 | Parous 1 174 497 |
Characteristics at recruitment | |||||||
Age, years (mean (s.d.)) | 56.2 (4.9) | 55.9 (4.8) | 56.6 (4.9) | 57.6 (5.1) | 58.6 (4.4) | 56.2 (5.1) | 56.1 (4.8) |
Socioeconomic status, lowest quintile (%) | 19.9 | 18.5 | 22.0 | 24.1 | 18.4 | 17.9 | 20.1 |
Current smoker (%) | 20.5 | 19.5 | 22.2 | 26.8 | 15.1 | 17.4 | 20.9 |
Alcohol 14+ units per week (%) | 6.2 | 6.3 | 6.1 | 5.0 | 5.0 | 8.5 | 5.9 |
Body mass index >30 kg m−2 (%) | 18.0 | 20.2 | 14.1 | 18.2 | 19.1 | 16.4 | 18.2 |
Strenuous exercise >1/week (%) | 20.9 | 21.3 | 20.3 | 18.9 | 21.1 | 22.1 | 20.8 |
Hormone therapy (HT), current use (%) | 33.5 | 33.5 | 33.4 | N/A | N/A | 31.7 | 33.7 |
Oral contraceptives, ever use (%) | 59.3 | 59.9 | 58.5 | 49.9 | 44.4 | 45.2 | 61.1 |
Nulliparous (%) | 10.8 | 11.2 | 10.0 | 13.6 | 11.6 | 100 | 0 |
Parity (mean (s.d.), in parous women) | 2.4 (1.1) | 2.4 (1.0) | 2.4 (1.1) | 2.4 (1.1) | 2.4 (1.1) | N/A | 2.4 (1.1) |
Ever breastfed (%, in parous women) | 67.8 | 68.1 | 67.5 | 65.8 | 70.6 | N/A | 67.8 |
Follow-up | |||||||
Person years (millions) | 11.9 | 7.3 | 4.4 | 1.5 | 2.1 | 1.3 | 10.6 |
Incident cancers (n) | |||||||
Oesophagus | 1186 | 720 | 433 | 258 | 247 | 163 | 1021 |
Oesophagus, squamous cell | 578 | 324 | 238 | 144 | 101 | 97 | 480 |
Oesophagus, adenocarcinoma | 399 | 272 | 117 | 74 | 96 | 36 | 362 |
Stomach | 1194 | 701 | 465 | 236 | 239 | 125 | 1067 |
Adenocarcinoma, gastric cardia | 283 | 176 | 97 | 60 | 48 | 29 | 253 |
Adenocarcinoma, non-cardia | 249 | 150 | 92 | 47 | 55 | 28 | 219 |
Abbreviation: N/A=not applicable.
Restricted to women with known age at menopause who have never used HT (see Materials and Methods).