Table 2. Adverse events occurring in >20% of patients.

Adverse event	All, n (%)	Grade 1, n (%)	Grade 2, n (%)	Grade 3, n (%)	Grade 4, n (%)
Nausea	15 (83%)	11 (61%)	3 (17%)	1 (6%)
Fatigue	12 (67%)	2 (11%)	8 (44%)	2 (11%)
Haemoglobin	11 (61%)	3 (17%)	6 (33%)	1 (6%)	1 (6%)
Dry skin	11 (61%)	7 (39%)	4 (22%)
Leukocytes	10 (55%)	7 (39%)	2 (11%)	1 (6%)
Hypoalbuminaemia	10 (55%)	7 (39%)	2 (11%)	1 (6%)
Alkaline phosphatase	9 (50%)	7 (39%)	1 (6%)	1 (6%)
Hypophosphataemia	8 (44%)	2 (11%)	3 (17%)	3 (17%)
Vomiting	8 (44%)	4 (22%)	2 (11%)	2 (11%)
Platelets	8 (44%)	5 (28%)	2 (11%)	1 (6%)
Anorexia	7 (39%)	3 (17%)	3 (17%)	1 (6%)
Neutrophils	6 (33%)		3 (17%)	3 (17%)
Creatinine	6 (33%)	3 (17%)	3 (17%)
Hyperglycaemia	5 (28%)	2 (11%)	2 (11%)	1 (6%)
Hyponatraemia	5 (28%)	4 (22%)		1 (6%)
Hypocalcaemia	5 (28%)	2 (11%)	3 (17%)
Headache	4 (22%)	2 (11%)	2 (11%)
Dry mouth	4 (22%)	4 (22%)
Taste alteration	4 (22%)	3 (17%)	1 (6%)