Table 3. Pharmacokinetic parameters for entinostat in plasma after Cycle 1, day 1.

		Pharmacokinetic parametersa
Dose (mg m −2 )	Number of patients	Tmax (h)	Cmax (ng ml −1 )	Vz/F (l m −2 )	Cls/F (l h −1  m −2 )	T1/2 (h)	AUC0−∝ (ng h ml −1 )
4	14	0.50 (0.23–1.50)	114.3±84.0	1368±435b	16.8±26.3b	129.7±88.5b	586.6±401.1b
5	4	0.25 (025–1.00)	109.0±66.0	1003±634	10.8±8.0	77.3±31.9	778.4±648.2
Total	18	0.42 (0.23–1.50)		1256±508c	14.9±22.0c	113.6±78.2c

Abbreviations: AUC_0−∝=area under the concentration-time curve from time 0 to infinity; Cl_s/F, C_max=maximal plasma concentration; T_max=time of the maximal plasma concentration; T_1/2=terminal half-life; V_zF=apparent volume of distribution.

^aValues are median (range) for T_max and mean±s.d. for AUC_0−∝, C_max, T_1/2, and V_z/F.

^bn=9.

^cn=13.