Table 2.
Change from baseline in MRI parameters (intent-to-treat population).
| Mean (SD) MRI parameters | IFN β-1a 44 µg sc tiw (n= 14) | No treatment (n = 15) | p-valuea |
|---|---|---|---|
| Number of T1 lesions | |||
| Day 1 | 16.4 (9.2) | 29.3 (17.4) | 0.9303 |
| Last visit | 16.9 (14.7) | 26.9 (15.5) | |
| Change | 0.4 (8.4) | −2.3 (10.3) | |
| T1 lesion volume (mm3) | |||
| Day 1 | 5138 (4755) | 6573 (5171) | 0.5557 |
| Last visit | 5563 (5436) | 6872 (5173) | |
| Change | 426 (2210) | 300 (1658) | |
| Number of T2 lesions | |||
| Day 1 | 34.6 (21.8) | 48.3 (28.2) | 0.2930 |
| Last visit | 30.8 (17.3) | 49.8 (32.9) | |
| Change | −3.9 (8.0) | 1.5 (13.9) | |
| T2 lesion volume (mm3) | |||
| Day 1 | 11 779 (8492) | 15 737 (10198) | 0.3261 |
| Last visit | 11 285 (8114) | 16 701 (11256) | |
| Change | −494 (1910) | 964 (5117) | |
IFN, interferon; MRI, magnetic resonance imaging; sc, subcutaneously; SD, standard deviation; tiw, three times weekly.
a
Testing for difference between treatment groups (Wilcoxon–Mann–Whitney test).