Table 2.
Effect of leaf methanol extract of Cotyledon orbiculata on hot-plate-induced nociception in mice.
| Treatment groups | Dose (mg/kg) | Response time (s) | ||||
|---|---|---|---|---|---|---|
| 0 min | 15 min | 30 min | 45 min | 60 min | ||
| PS | 0.25 mL | 4.13 ± 0.13 | 6.63 ± 0.60 | 4.38 ± 0.78 | 3.38 ± 0.68 | 2.75 ± 0.31 |
|
| ||||||
| C. orbiculata | 100 | 6.63 ± 0.92 | 10.25 ± 1.46 | 11.75** ± 1.07 | 7.13 ± 1.27 | 5.13 ± 0.08 |
| 200 | 6.63 ± 0.85 | 7.38 ± 1.08 | 12.38+ ± 1.43 | 6.88 ± 1.57 | 6.25 ± 1.45 | |
| 400 | 5.25 ± 0.47 | 19.13* ± 5.01 | 26.63++ ± 3.35 | 22.63+ ± 3.41 | 24.5++ ± 2.55 | |
|
| ||||||
| Morphine | 10 | 3.38 ± 0.64 | 26.63++ ± 4.83 | 36.50++ ± 6.55 | 22.88++ ± 2.93 | 16.63++ ± 2.07 |
|
| ||||||
| DMSO | 0.25 mL | 5.00 ± 0.76 | 6.13 ± 0.99 | 3.88 ± 0.38 | 4.75 ± 0.86 | 4.50 ± 0.91 |
*P < 0.05, **P < 0.025, + P < 0.02, ++ P < 0.001 versus physiological saline control, ANOVA (n = 8). The response time in seconds was expressed as Mean ± SEM.
PS: physiological saline.
DMSO: dimethylsulfoxide.