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. 2011 Mar 23;31(12):4720–4730. doi: 10.1523/JNEUROSCI.3076-10.2011

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Copyright © 2011 the authors 0270-6474/11/314720-11$15.00/0

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Figure 4. — Comparison of brain kinetics and performance in detecting neuroinflammatory changes between two TSPO ligands, [¹¹C]AC-5216 and [¹⁸F]FEDAA1106, in 11-month-old PS19 Tg mice (n = 8). A, B, Hippocampal (closed circles) and striatal (open circles) time-radioactivity curves in mice following intravenous injection of [¹¹C]AC-5216 (A) and [¹⁸F]FEDAA1106 (B). Error bars represent SE. C, Scatterplot of hippocampal BP_ND for [¹⁸F]FEDAA1106 against that for [¹¹C]AC-5216 in each individual. Significant correlation between these BP_ND estimates was observed (r² = 0.71, p < 0.01 by F test), while [¹¹C]AC-5216 yielded larger values and better detectability of subtle inflammations than did [¹⁸F]FEDAA1106. Solid line indicates the regression for all mice.