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. 2011 Mar 23;31(12):4720–4730. doi: 10.1523/JNEUROSCI.3076-10.2011

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Copyright © 2011 the authors 0270-6474/11/314720-11$15.00/0

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Figure 6. — PET and autoradiographic images of TSPO upregulation in old APP23 mice. A, Coronal PET images containing the striatum (top) and hippocampus (bottom) in 28-month-old nTg and 26-month-old APP23 Tg mice. Images were generated by averaging dynamic scan data at 30–60 min after [¹¹C]AC-5216 injection. B, Ex vivo autoradiographic sections containing the hippocampus (at bregma −2.8 mm) in 27-month-old nTg and 30-month-old APP23 Tg mice. Brains were collected at 30 min after intravenous injection of [¹¹C]AC-5216. C, Amyloidosis-associated in vitro autoradiographic [¹¹C]AC-5216 signals in a 24-month-old APP23 Tg mouse brain section. The autoradiographic section (left) was subsequently stained with an amyloid dye, FSB (middle), and colocalization of radiotracer binding and plaque deposition was assessed in a merged image (right).