Table 2.
Predicted toxicities (based on results from the on-line program OSIRIS Property Explorer). The most active compounds in table 1 are given in bold type. None of the compounds were obviously toxic in the cell culture assay when added alone, at the highest dose tested.
| Comp. | Expected Toxcity
|
|||
|---|---|---|---|---|
| Mutagenic | Tumorigenic | Irritant | Reproduct | |
| 1 | high | low | mid | low |
| 2 | mid | low | low | low |
| 3 | high | low | mid | low |
| 4 | low | low | low | low |
| 5 | low | low | low | low |
| 6 | low | low | high | low |
| 7 | high | high | mid | low |
| 8 | low | low | low | low |
| 9 | low | low | low | low |
| 10 | high | low | mid | low |
| 11 | mid | low | low | low |
| 12 | low | low | low | low |
| 13 | low | low | low | low |
| 14 | low | low | low | low |
| 15 | low | low | low | low |
| 16 | low | low | low | low |
| 17 | low | low | low | low |
| 18 | low | low | low | low |
| 19 | high | low | high | low |
| 20 | low | low | low | low |
| 21 | mid | low | low | low |
| 22 | low | low | low | low |