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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Bioorg Med Chem. 2011 Nov 16;20(1):368–376. doi: 10.1016/j.bmc.2011.10.091

Table 2.

Predicted toxicities (based on results from the on-line program OSIRIS Property Explorer). The most active compounds in table 1 are given in bold type. None of the compounds were obviously toxic in the cell culture assay when added alone, at the highest dose tested.

Comp. Expected Toxcity
Mutagenic Tumorigenic Irritant Reproduct
1 high low mid low
2 mid low low low
3 high low mid low
4 low low low low
5 low low low low
6 low low high low
7 high high mid low
8 low low low low
9 low low low low
10 high low mid low
11 mid low low low
12 low low low low
13 low low low low
14 low low low low
15 low low low low
16 low low low low
17 low low low low
18 low low low low
19 high low high low
20 low low low low
21 mid low low low
22 low low low low