Figure 4. Temporal sequence of pathway alterations within subtypes.

The classical and neural subtypes did not result in any significant orderings of pathway alterations. Mutations included as alterations of each pathway are defined in Table 1. Each arrow indicates the order in which the two alterations arise. The first number represents the frequency with which the displayed temporal sequence occurs. The second number represents the percent of all bootstrap iterations in which the order determined acts as the dominant temporal sequence. A) The proneural subtype. B) The mesenchymal subtype.