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. 2012 Jan 5;8(1):e1002339. doi: 10.1371/journal.pcbi.1002339

Table 1. Contribution of telaprevir and PR treatment to the antiviral blockage and infected-cell clearance rates in treatment-naïve patient population.

Variant Name Level of resistance Antiviral blockage log10(1- ε) infected-cell clearance δ (d−1)
PegIFN/RBV telaprevir
Median 5th% 95th% Median 5th% 95th% Median 5th% 95th%
WT None −1.09 −1.28 −0.76 −2.27 −2.68 −1.69 0.62 0.36 1.42
R155K Lower −1.09 −1.28 −0.76 −2.51 −3.40 −1.28 0.65 0.36 1.54
V36A Lower −1.09 −1.28 −0.76 −2.39 −3.25 −1.19 0.65 0.36 1.49
A156T Higher −1.09 −1.28 −0.76 −0.01 −0.02 0.00 0.29 0.24 0.36
V36M/R155K Higher −1.09 −1.28 −0.76 0.00 −0.01 0.00 0.29 0.24 0.36