Table 1. Contribution of telaprevir and PR treatment to the antiviral blockage and infected-cell clearance rates in treatment-naïve patient population.
Variant Name | Level of resistance | Antiviral blockage log10(1- ε) | infected-cell clearance δ (d−1) | |||||||
PegIFN/RBV | telaprevir | |||||||||
Median | 5th% | 95th% | Median | 5th% | 95th% | Median | 5th% | 95th% | ||
WT | None | −1.09 | −1.28 | −0.76 | −2.27 | −2.68 | −1.69 | 0.62 | 0.36 | 1.42 |
R155K | Lower | −1.09 | −1.28 | −0.76 | −2.51 | −3.40 | −1.28 | 0.65 | 0.36 | 1.54 |
V36A | Lower | −1.09 | −1.28 | −0.76 | −2.39 | −3.25 | −1.19 | 0.65 | 0.36 | 1.49 |
A156T | Higher | −1.09 | −1.28 | −0.76 | −0.01 | −0.02 | 0.00 | 0.29 | 0.24 | 0.36 |
V36M/R155K | Higher | −1.09 | −1.28 | −0.76 | 0.00 | −0.01 | 0.00 | 0.29 | 0.24 | 0.36 |