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. 2012 Jan 5;8(1):e1002440. doi: 10.1371/journal.pgen.1002440

Table 2. CpG methylation profiling of 12 maternal and 3 paternal imprinting control regions.

Gene locus Chr. Extents of the ICRs Average methylation levels
Start End Wild-type oocyte DnmtLl−/− oocyte Sperm Blastocyst ESC
Maternally methylate imprinted genes Nespas-Gnas 2 174,119,863 174,126,564 99.3% 5.6% 3.9% 38.2% 55.9%
Gnas (exon1A) 2 174,150,877 174,154,638 95.2% 3.5% 4.1% 20.4% 7.8%
Peg10 6 4,696,743 4,699,483 95.9% 6.7% 5.5% 31.8% 57.1%
Mest 6 30,684,932 30,689,966 96.5% 2.3% 4.2% 30.7% 52.6%
Peg3 7 6,679,787 6,684,257 98.1% 3.0% 2.5% 32.1% 42.8%
Snrpn 7 67,147,381 67,151,583 94.1% 35.7% 4.6% 34.3% 64.9%
Kcnq1ot1 7 150,480,736 150,482,810 97.9% 2.2% 4.3% 34.1% 52.0%
Plagl1 10 12,809,697 12,812,131 99.9% 1.3% 7.4% 35.4% 53.0%
Grb10 11 11,925,127 11,927,100 98.0% 1.2% 5.3% 38.5% 78.7%
Zrsr1 11 22,871,610 22,874,212 94.1% 5.2% 6.8% 34.8% 47.0%
Igf2r 17 12,934,169 12,935,816 99.1% 0.9% 3.8% 44.2% 53.2%
Impact 18 13,130,435 13,133,510 97.2% 2.4% 6.6% 43.1% 38.6%
Paternally methylated imprinted genes H19 7 149,764,673 149,771,930 13.5% 0.6% 96.5% 40.8% 65.5%
Rasgrf1 9 89,767,090 89,775,128 7.4% 0.7% 92.0% 25.2% 59.4%
Dlk1-Meg3 12 110,762,703 110,773,093 18.9% 0.9% 96.8% 32.4% 83.1%

†: : The extents of each region in germ cells were determined by bisulfite sequencing study [39].