Table 2. Discriminatory power of features.

Feature name	Significance (p<0.0025, corrected for multiple comparison)
	Normal v/s Abnormal	Fibrocystic v/s Metastatic
Cell volume	Yes	Yes
Nuclear volume	Yes	Yes
Nucleus to cytoplasm ratio	Yes	Yes
Nuclear sphericity	Yes	Yes
Number of nucleoli	Yes	No
Total nucleolar volume	No	No
Variance in nucleolar volume	Yes	No
Average nucleolar margination	Yes	No
Variance in nucleolar margination	Yes	Yes
Total nuclear content	Yes	Yes
Mean nuclear content	Yes	Yes
Variance in nuclear content	Yes	No
Skew in nuclear content	Yes	No
Kurtosis in nuclear content	Yes	Yes
Low density volume fraction	Yes	No
Medium density volume fraction	Yes	Yes
High density volume fraction	Yes	No
Low density content fraction	Yes	Yes
Medium density content fraction	Yes	Yes
High density content fraction	Yes	Yes
Number of low density clumps	Yes	Yes
Number of medium density clumps	Yes	Yes
Number of high density clumps	Yes	Yes
Low density compactness	Yes	Yes
Medium density compactness	Yes	No
High density compactness	Yes	Yes
Medium-high density compactness	Yes	Yes
Average extinction ratio (low-medium)	Yes	No
Average extinction ratio (low-high)	Yes	Yes
Average extinction ratio (low-mediumhigh)	Yes	Yes
Average distance from nucleus center to low density regions	Yes	Yes
Average distance from nucleus center to medium density regions	No	Yes
Average distance from nucleus center to high density regions	Yes	Yes
Average distance from nucleus center to medium-high density regions	Yes	Yes
Average centroidal distance from nucleus center to low density regions	Yes	Yes
Average centroidal distance from nucleus center to medium density regions	No	No
Average centroidal distance from nucleus center to high density regions	Yes	No
Average centroidal distance from nucleus center to medium-high density regions	No	No
Markovian contrast	Yes	Yes
Markovian correlation	Yes	Yes
Markovian energy	Yes	Yes
Markovian heterogeneity	Yes	Yes