Table 1. siRNAs perturbing infectious HCV secretion.
Percent Inhibition* | ||||
Gene | Infectious HCV | Host Gene RNA | Intra-:Extra- cellular virus | Function |
SAR1A | 80 | 64 | 4.10 | ER -> Golgi |
CYTH3 | 87 | 75 | 3.35 | Golgi function |
CLINT1 | 77 | 70 | 2.99 | Golgi sorting |
PI4KB | 90 | 76 | 13.73 | Golgi sorting |
PRKD1 | 73 | 75 | 3.43 | Golgi sorting |
AP1M1 | 85 | 81 | 2.32 | Golgi Sorting |
PACSIN3 | 76 | 91 | 2.71 | Vesicle trafficking |
ARF3 | 75 | 73 | 2.18 | Golgi trafficking |
RAB11A | 82 | 61 | 3.51 | Exocytosis |
RAB3D | 69 | 80 | 9.94 | Exocytosis |
VAMP1 | 81 | 77 | 5.04 | Exocytosis |
RHOA | 75 | 71 | 2.65 | Actin/remodeling |
GIT1 | 71 | 69 | 3.04 | Actin/remodeling |
WAS | 71 | 91 | 5.87 | Actin/remodeling |
*as compared to siIRRelevant treated cells.