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. 2011 Nov 16;31(46):16855–16863. doi: 10.1523/JNEUROSCI.3235-11.2011

Figure 4.

Figure 4.

Subtracting/adding BK current decreases/increases burstiness. A, Bursting activity of a GH4C1 cell in control conditions. B, During application of a negative BK conductance via dynamic clamp (gBK = −1 nS), the electrical activity switches to mostly spiking. C, Summary of the effect of negative artificial BK conductance on burstiness (gBK = −0.5 nS, p < 0.02, n = 7). D, Summary of the effect of positive artificial BK conductance to mostly spiking cells (8 of 12 had BF ≤ 0.3) in control saline (gBK = 0.5 nS, p < 0.02). Data are summarized using the median and interquartile range, and significance was assessed using the nonparametric Wilcoxon test.