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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: Clin Rev Bone Miner Metab. 2011 Dec;9(3-4):187–197. doi: 10.1007/s12018-011-9104-8

Table 1.

Effects of Inhibitors on stone formation

INHIBITOR Nucleation Inhibitor Growth Inhibitor Aggregation inhibitor Attachment inhibitor
Citrate I I I I
Pyrophosphate I I I/NI ND
Phytate * I ND ND
Magnesium I I I I (high conc.)
Osteopontin I I I/NI I
THP NI NI I/NI I
UPF- 1 * I I I
Bikunin I I I I
*

property was not explicitly tested but is likely to be present, as nucleation appears to always track with growth inhibition; I, inhibitory activity demonstrated; NI, inhibitory activity not demonstrated, ND, Inhibitory activity not determined; I/NI, both inhibitory and promoter activity noted