Skip to main content
. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: Nat Struct Mol Biol. 2011 Dec 4;19(1):48–55. doi: 10.1038/nsmb.2178

Figure 7. Schematic model of Ndc10 interactions on budding yeast centromeres.

Figure 7

Cbf1 and CBF3 core recognize CDEI and CDEIII, respectively. Ndc10 does not have sequence-specific DNA contacts, but it binds in defined register through its interactions with Cbf1 and CBF3 core. We propose that these contacts bring CDEI and CDEIII together to form a loop. Two potential loop configurations are shown. The Scm3:Cse4:H4 heterotrimeric complex can be recruited through Scm3–Ndc10 interaction.