Table 1.
Characteristics of Adult Subjects
| Study*
|
|||
|---|---|---|---|
| COGA N=1800 |
COGEND N=2666 |
FSCD N=1166 |
|
|
| |||
| Sex, N (%) | |||
| Male | 971 (53.9) | 1,018 (38.2) | 579 (49.7) |
| Female | 829 (46.1) | 1,648 (61.8) | 587 (50.3) |
|
| |||
| Age, years | |||
| Mean ± sd | 43.1 ± 11.4 | 36.5 ± 5.5 | 37.0 ± 8.8 |
| Range | 18.0–79.0 | 25.0–47.0 | 18.0–60.0 |
|
| |||
| Race, N (%) | |||
| European American | 1353 (75.2) | 1981 (74.3) | 558 (47.9) |
| African American | 447 (24.8) | 685 (25.7) | 608 (52.1) |
|
| |||
| DSM-IV Alcohol Dependence | |||
| Diagnosis, N (%) | 1139 (63.3) | 612 (23.0) | 547 (46.9) |
|
| |||
| FTND Nicotine Dependence | |||
| Never Smokers, N (%) | 509 (30.3) | 0 | 505 (43.3) |
| Nicotine Dependent, N (%) | 803 (47.9) | 1407 (52.8) | 445 (38.2) |
| Not Nicotine Dependent, N (%) | 366 (21.8) | 1259 (47.2) | 216 (18.5) |
|
| |||
| DSM-IV Cocaine Dependence | |||
| Diagnosis, N (%) | 481 (26.7) | 219 (8.2) | 551 (47.3) |
|
| |||
| rs1229984** | |||
| AA | 5 (0/5) | 6 (0/6) | 1 (0/1) |
| AG | 96 (38/58) | 162 (21/141) | 51 (20/31) |
| GG | 1699 (1101/598) | 2498 (591/1907) | 1114 (527/587) |
*
COGA: Collaborative Study on the Genetics of Alcoholism
COGEND: Collaborative Genetic Study of Nicotine Dependence
FSCD: Family Study of Cocaine Dependence
**
Total N (Case n/Control n)