Table 3.
Association of rs1229984 with DSM-IV alcohol dependence and maximum drinks consumed in a 24-hour period.
| Outcome | ||||||||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| Ethnicity | MAF | DSM-IV Alcohol Dependencea | Maximum Drinks in 24-hour periodb | |||||
| N | OR (95% CI) | p | N | β (95% CI) | p | |||
| COGA | EA | 0.03 | 1250 | 0.25 (0.12, 0.48) | 5.97 × 10−5 | 1246 | −0.42 (−0.58, −0.25) | 4.61 × 10−7 |
| AA | 0.01 | 428 | 0.37 (0.06, 1.89) | 2.48 × 10−1 | 425 | −0.31 (−0.74, 0.12) | 1.57 × 10−1 | |
|
| ||||||||
| COGEND | EA | 0.04 | 1981 | 0.38 (0.23, 0.63) | 2.19 × 10−4 | 1981 | −0.22 (−0.31, −0.12) | 9.15 × 10−6 |
| AA | 0.01 | 685 | 0.47 (0.10, 2.23) | 3.42 × 10−1 | 685 | −0.002 (−0.41, 0.41) | 9.92 × 10−1 | |
|
| ||||||||
| FSCD | EA | 0.03 | 558 | 0.29 (0.10, 0.85) | 2.32 × 10−2 | 550 | −0.24 (−0.50, 0.01) | 6.19 × 10−2 |
| AA | 0.02 | 608 | 0.40 (0.13, 1.28) | 1.24 × 10−1 | 588 | −0.70 (−1.11, −0.28) | 9.97 × 10−4 | |
|
| ||||||||
| Meta-Analysis | EA | 3789 | 0.32 (0.22, 0.47) | 6.03 × 10−9 | 3777 | −0.27 (−0.35, −0.19) | 1.33 × 10−11 | |
| AA | 1721 | 0.41 (0.18, 0.93) | 3.21 × 10−2 | 1698 | −0.34 (−0.58, −0.10) | 6.00 × 10−3 | ||
| Combined | 5510 | 0.34 (0.24, 0.48) | 6.57 × 10−10 | 5475 | −0.28 (−0.35, −.020) | 3.24 × 10−13 | ||
a
Logistic regression adjusted for sex, age (in quartiles), and nicotine and cocaine dependence.
b
Linear regression of the log transformed number of drinks adjusted for sex, age (in quartiles), and nicotine and cocaine dependence.
AA=African American; EA=European American; MAF=minor allele frequency; OR=odds ratio; CI=confidence interval.