. Author manuscript; available in PMC: 2013 Feb 1.

Published in final edited form as: Pharm Res. 2011 Sep 9;29(2):535–545. doi: 10.1007/s11095-011-0580-9

Table I.

Pharmacokinetics of [¹⁴C]GlySar During Fed and Fasted Conditions in Wild-Type and Pept1 Knockout Mice after 5 nmol/g Intravenous Bolus Doses of Dipeptide

Parameter	Wild-Type		Pept1 Knockout
Parameter	Fed	16-Hr Fast	Fed	16-Hr Fast
CL (μl/min)	216 ± 19	253 ± 21	223 ± 13	221 ± 11
Vdss (ml)	8.6 ± 1.2	13.2 ± 2.0 ^D	8.1 ± 0.8	6.9 ± 0.6 ^D
MRT (min)	33.5 ± 1.8	39.1 ± 2.0 ^D	32.9 ± 1.6	29.0 ± 1.6 ^D
T_1/2 (min)	44.6 ± 5.5	59.1 ± 6.3 ^D	37.9 ± 2.6	34.1 ± 2.4 ^D

Data are represented as mean ± SE (n = 6).

CL, total plasma clearance; Vdss, volume of distribution steady-state; MRT, mean residence time; T_1/2 , terminal half-life.

One-way ANOVA and Tukey method of multiple comparisons were performed to test for differences among treatment groups: ^ARepresents significant differences between fed and fasted conditions in wild-type mice; ^Brepresents significant differences between fed and fasted conditions in Pept1 knockout mice; ^Crepresents significant differences between wild-type and Pept1 knockout mice in fed conditions; and ^Drepresents significant differences between wild-type and Pept1 knockout mice in fasted conditions.