. Author manuscript; available in PMC: 2013 Feb 1.

Published in final edited form as: Pharm Res. 2011 Sep 9;29(2):535–545. doi: 10.1007/s11095-011-0580-9

Table II.

Pharmacokinetics of [¹⁴C]GlySar During Fed and Fasted Conditions in Wild-Type and Pept1 Knockout Mice after 5 nmol/g Oral Doses of Dipeptide

Parameter	Wild-Type		Pept1 Knockout
Parameter	Fed	16-Hr Fast	Fed	16-Hr Fast
AUC_{0-360 min} (μM•min)	415 ± 11 ^A,^C	581 ± 46 ^A,^D	268 ± 8 ^C	302 ± 13 ^D
C_max (μM)	1.67 ± 0.03 ^A,^C	2.80 ± 0.10 ^A,^D	1.15 ± 0.07 ^C	1.21 ± 0.03 ^D
T_max (min)	47.5 ± 4.6	52.5 ± 3.4	45.0 ± 3.9	55.0 ± 7.4
T_1/2 (min)	350 ± 16	410 ± 47	374 ± 31	401 ± 47

Data are represented as mean ± SE (n = 6).

AUC_{0-360 min}, area under the plasma concentration-time curve from 0 to 360 min; C_max, peak plasma concentration; T_max, time to reach peak plasma concentration; T_1/2, terminal half-life.

One-way ANOVA and Tukey method of multiple comparisons were performed to test for differences among treatment groups: ^ARepresents significant differences between fed and fasted conditions in wild-type mice; ^Brepresents significant differences between fed and fasted conditions in Pept1 knockout mice; ^Crepresents significant differences between wild-type and Pept1 knockout mice in fed conditions; and ^Drepresents significant differences between wild-type and Pept1 knockout mice in fasted conditions.