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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Anesth Analg. 2011 Sep 29;115(2):297–304. doi: 10.1213/ANE.0b013e3182320559

Figure 7.

Figure 7

The differential effects of MOC-carboetomidate (27 mg/kg) and etomidate (2 mg/kg) on adrenocortical function in the rat. These doses correspond to twice the respective ED50s for loss of righting reflexes. Adrenocorticotropic hormone1–24 was given simultaneously with sedative-hypnotic to stimulate corticosterone production and serum corticosterone concentrations were measured 30 minutes later. Four rats were studied in each group. Average corticosterone concentrations (±SD) were 460 ± 140 ng/ml in the vehicle control group, 90 ± 44 ng/ml in the etomidate group, and 610 ± 280 ng/ml in the MOC-carboetomidate group. *, P < 0.05; **, P < 0.01; NS, no significant difference.