Skip to main content
. 2011 Dec 12;6:3323–3334. doi: 10.2147/IJN.S26305

Table 1.

Particle size, zeta potential, and encapsulation efficiency of PTX-loaded nanomicelles

Micelles PTX:CS-VES (charge ratio) Particle size (nm) Polydispersion Zeta potentiala (mV) EEb (%) DLc (%)
Blank micelles 252.3 ± 6.0 0.459 ± 0.009 24.9 ± 1.2
PTX-micelles 1:10 326.3 ± 3.5 0.475 ± 0.013 22.8 ± 3.3 81.82 ± 0.95 7.52 ± 0.08
PTX-micelles 1:5 365.6 ± 1.3 0.390 ± 0.011 19.1 ± 2.5 82.03 ± 0.77 14.09 ± 0.11
PTX-micelles 1:3 380.8 ± 0.9 0.357 ± 0.030 19.5 ± 1.7 81.12 ± 0.56 21.37 ± 0.17
a

Notes: Measurement was performed in deionized water (pH 7);

b

drug encapsulation efficiency = (amount of drug loaded in the micelles/amount of drug added during fabrication) × 100;

c

drug loading ratio = (amount of drug loaded in the micelles/the total amount of drug in the micelles and CS-VES conjugate used in the process) × 100. Mean ± standard deviation, n = 3.

Abbreviations: CS-VES, chitosan/vitamin E succinate; DL, drug loading ratio; EE, encapsulation efficiency; PTX, paclitaxel.