Table 1.
Particle size, zeta potential, and encapsulation efficiency of PTX-loaded nanomicelles
| Micelles | PTX:CS-VES (charge ratio) | Particle size (nm) | Polydispersion | Zeta potentiala (mV) | EEb (%) | DLc (%) |
|---|---|---|---|---|---|---|
| Blank micelles | – | 252.3 ± 6.0 | 0.459 ± 0.009 | 24.9 ± 1.2 | – | – |
| PTX-micelles | 1:10 | 326.3 ± 3.5 | 0.475 ± 0.013 | 22.8 ± 3.3 | 81.82 ± 0.95 | 7.52 ± 0.08 |
| PTX-micelles | 1:5 | 365.6 ± 1.3 | 0.390 ± 0.011 | 19.1 ± 2.5 | 82.03 ± 0.77 | 14.09 ± 0.11 |
| PTX-micelles | 1:3 | 380.8 ± 0.9 | 0.357 ± 0.030 | 19.5 ± 1.7 | 81.12 ± 0.56 | 21.37 ± 0.17 |
a
Notes: Measurement was performed in deionized water (pH 7);
b
drug encapsulation efficiency = (amount of drug loaded in the micelles/amount of drug added during fabrication) × 100;
c
drug loading ratio = (amount of drug loaded in the micelles/the total amount of drug in the micelles and CS-VES conjugate used in the process) × 100. Mean ± standard deviation, n = 3.
Abbreviations: CS-VES, chitosan/vitamin E succinate; DL, drug loading ratio; EE, encapsulation efficiency; PTX, paclitaxel.