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. Author manuscript; available in PMC: 2012 Jan 6.
Published in final edited form as: Clin Immunol. 2008 Oct 28;130(1):7–15. doi: 10.1016/j.clim.2008.08.015

Figure 3.

Figure 3

LPS tolerance is an example of gene-specific regulation of the inflammatory response. Following LPS stimulation of naïve macrophages, both class T and class NT promoters recruit transcription factors and display increased histone acetylation, histone H3K4 trimethylation, and accessibility (represented by yellow starburst). In tolerant macrophages stimulated with LPS, class T promoters are deacetylated and inaccessible. Class NT promoters, on the other hand, are inducibly reacetylated, remethylated, and made accessible with faster kinetics.