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. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: Biochem Pharmacol. 2011 Jul 23;82(9):1100–1109. doi: 10.1016/j.bcp.2011.07.078

Figure 5. Effect of oral administration of VCN-2 alone and in combination with DTL on tumor regression of PC3 xenografts.

Figure 5

The nu/nu nude mice were injected with 2 × 106 PC3 cells suspensions in 100 μl of PBS, subcutaneously into one flank and divided in to four groups. Treatment consisted of corn oil (control), VCN-2 (1 mg/kg b.w.), DTL (0.01 mg/kg b.w.), and both, VCN-2 and DTL, in 100 μl by oral gavage alternate day. Experimental details are given in the Methods section. Animals were examined daily for signs of tumor growth and body weights were recorded (panel A). Photographs of animals were taken at day 1, day 10, day 20, day 40, and day 60 after subcutaneous injection, are shown for all groups (supplementary data). Weights and photographs of tumors were also taken at day 60. * P < 0.001 for VCN-2 and DTL co-administration when compared to control as well as either of the single drug treatment (panel B). Tumors were measured in two dimensions using calipers and time-course analysis of tumor regression was performed during the study (panel C).