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A model of the PIDDosome for caspase-2 activation. The schematic model is based on the crystal structure of the PIDD-DD:RAIDD-DD core complex, which forms the center rings mediating oligomerization. The RAIDD CARD occupies the outer part of the PIDDosome bringing seven caspase-2 molecules into proximity facilitating dimerization. Adapted from Park et al30
