Table 1. Examples from various organisms where loss of the autophagic machinery suppresses physiological cell death.
Organism | Tissue/cells | Autophagy inhibition |
---|---|---|
Arabidopsis | Tracheary elements | Atg5 mutant |
Dictyostelium | Fruiting body formation | Atg1 mutants |
Drosophila | Removal of larval salivary glands | Atg mutants |
Drosophila | Removal of larval midgut | Atg2, Atg18 mutants and Atg1, Atg18 knockdown |
Mammals | Ras-expressing HOSE cells | Atg5 and Atg7 knockdown |
Mammals | HCN after insulin withdrawal | Atg7 knockdown |