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. 2011 Nov 18;19(1):13–20. doi: 10.1038/cdd.2011.162

Table 1. The PIDDosomes.

Platform Stimulus Components Outcome References
Caspase-2 PIDDosome DNA damage Heat Shock PIDD (PIDD-CC) RAIDD Caspase-2 Caspase-2 activation Cell death Drug resistance Tinel et al.4, 6 Tu et al.11 Oliver et al.12
NEMO PIDDosome DNA damage PIDD (PIDD-C) RIP1 NEMO NEMO modifications NF-κB activation Janssens et al.37
PCNA PIDDosome UV PIDD (PIDD-C) PCNA RFC5, RFC4 PCNA monoUb DNA repair Translesion DNA synthesis Logette et al.41
DNA-PKc PIDDosome DNA damage PIDD RAIDD DNA-PK Caspase-2 phosphorylation Cell cycle checkpoint DNA repair C Du and A Villunger (personal communications)