Caspase-2
PIDDosome |
DNA damage
Heat Shock |
PIDD (PIDD-CC)
RAIDD
Caspase-2 |
Caspase-2 activation
Cell death
Drug resistance |
Tinel et al.4, 6
Tu et al.11
Oliver et al.12
|
NEMO
PIDDosome |
DNA damage |
PIDD (PIDD-C)
RIP1
NEMO |
NEMO modifications
NF-κB activation |
Janssens et al.37
|
PCNA
PIDDosome |
UV |
PIDD (PIDD-C)
PCNA
RFC5, RFC4 |
PCNA monoUb
DNA repair
Translesion DNA synthesis |
Logette et al.41
|
DNA-PKc
PIDDosome |
DNA damage |
PIDD
RAIDD
DNA-PK |
Caspase-2 phosphorylation
Cell cycle checkpoint
DNA repair |
C Du and A Villunger (personal communications) |