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Cathepsin X inhibitor abrogates cytokine production in DCs, which were differentiated and subsequently activated (20 ng/ml LPS) in the presence or absence of the cathepsin X inhibitor. Cell-free supernatants were collected after 48 h and after the addition of LPS and then analyzed using ELISA. Student’s t-tests were calculated for control DCs versus mAb 2F12-treated DCs. Mean control DC responses from three independent experiments are shown.
