Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Reactions and conditions: (a) DCC, NHS, DMF 80 °C, 18 h, 76%. (b) Ph(CH2)2Br, K2CO3, acetone, r.t., 20 h, (±)-4, 98%. (b') Ph(CH2)2OH, DIAD, PPh3, THF, r.t., 20 h, (−)-4, 90%. (c) H2, 10% w/w Pd/C, MeOH, r.t., 4 h, quant. (d) (S)-2-methylbutanoic acid, EDCl, HOBt, CH2Cl2, r.t., 16 h, 73%.
