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. 2011 Nov 7;7:1504–1507. doi: 10.3762/bjoc.7.175

Scheme 3.

Scheme 3

Reactions and conditions: (a) (CH2O)n, MeOH, r.t., 2 h then, (S)-2-methylbutanoic acid and 7, r.t. 18 h, 61%. (b) H2, 10% w/w Pd/C, MeOH, r.t., 10 h. (c) 1-pyrenemethylamine hydrochloride, Et3N, EDCl, DMAP, CH2Cl2, r.t., 24 h, 80% over two steps.