Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
A) Formation of the trichloroleucyl starter unit of barbamide (7) synthesis through the non-heme iron(II)-dependent halogenases BarB1 and BarB2. B) Formation of cyclopropane and vinyl chloride functional groups in curacin A (9) and jamaicamide A (8) biosynthesis, respectively. The halogenated carbon is highlighted with a black dot. ACP: Acyl carrier protein; HCS: HMG-CoA synthase-like enzyme; Hal: Halogenase; ECH1: Dehydratase; ECH2: Decarboxylase; ER: Enoyl reductase.
