Table 2.
Comparison of the amino acid homology of the structural domains of the various bat-derived plasminogen activators with human t-PA
| D. rotundus (DSPAα1), % | D. youngi, % | D. eucadata, % | C. perspicillata, % | |
|---|---|---|---|---|
| t-PA Finger domain (38 residues) | 57.89 | 70.4 | 81.57 | 84.21 |
| t-PA EGF domain (34 residues) | 82.35 | 76.47 | 82.35 | 82.35 |
| t-PA K1 domain (82 residues) | 69.51 | 68.29 | 78.05 | 84.14 |
| t-PA K2 domain (82 residues) | – | – | 56.09 | 63.41 |
| t-PA Protease domain (264 residues) | 77.27 | 75.00 | 83.33 | 85.61 |
| Overall domain identity with t-PA | 74.40 | 73.20 | 77.80 | 81.40 |