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Emodin-evoked increase in ISC of the mucosa/submucosa preparations of the rat distal colon. (A) Addition of emodin (100 µM) to the basolateral side of the mucosa/submucosa preparation evoked an increase in ISC, while addition to the apical side evoked only a small increase in ISC. Arrowhead indicates the time of emodin addition. (B) Concentration–response relationship for emodin-evoked ΔISC in the mucosa/submucosa preparations. The EC50 was 75.0 µM.
