Table 2.
Hemodynamic response to adrenergic blockade
| Baseline | β-Blockade | α- and β -Blockade | |
|---|---|---|---|
| Young | |||
| Heart rate, beats/min | 59 ± 4 | 49 ± 2* | 53 ± 2*† |
| ΔHeart rate, beats/min | −10 ± 2* | −6 ± 2*† | |
| Systolic BP, mmHg | 114 ± 3 | 113 ± 2 | 109 ± 3*† |
| ΔSystolic BP, mmHg | −2 ± 2 | −6 ± 2*† | |
| Diastolic BP, mmHg | 63 ± 1 | 61 ± 2 | 58 ± 3*† |
| ΔDiastolic BP, mmHg | −1 ± 1 | −4 ± 2*† | |
| Mean BP, mmHg | 84 ± 1 | 84 ± 1 | 80 ± 2*† |
| ΔMean BP, mmHg | −1 ± 1 | −4 ± 2*† | |
| Older | |||
| Heart rate, beats/min | 63 ± 4 | 55 ± 5*‡ | 59 ± 5*†‡ |
| ΔHeart rate, beats/min | −8 ± 2* | −3 ± 2*† | |
| Systolic BP, mmHg | 129 ± 3‡ | 127 ± 3‡ | 113 ± 2*†‡ |
| ΔSystolic BP, mmHg | −2 ± 2 | −15 ± 2*†‡ | |
| Diastolic BP, mmHg | 76 ± 2‡ | 76 ± 3‡ | 69 ± 2*†‡ |
| ΔDiastolic BP, mmHg | 0 ± 2 | −8 ± 1*†‡ | |
| Mean BP, mmHg | 95 ± 2‡ | 94 ± 2‡ | 86 ± 1*†‡ |
| ΔMean BP, mmHg | −1 ± 1 | −9 ± 1*†‡ |
Data were obtained 1) at baseline (i.e., before beginning adrenergic blockade priming doses), 2) after completion of the β -adrenergic priming dose (β-blockade), and 3) subsequent to completion of the α-blockade priming dose (i.e., during combined α- and β -blockade).
*
P < 0.05 vs. baseline (same age group).
†
P < 0.05 vs. β-blockade (same age group).
‡
P < 0.05 vs. young (same time point).