Fig. 3.

Upregulation of a highly significant Ingenuity pathway analysis (IPA) gene network (IPA network score = 50) in response to endurance training in high responders (A), but not in low responders (B). Aerobic training was found to be associated with differential increases (>1.5 FC, dark gray boxes) and decreases (>1.4 FC, light gray boxes) in gene expression mostly in the high responders to aerobic training. Those genes that were upregulated in the low responders were upregulated to a significantly greater extent in high responders (Table 2). The network involves a number of extracellular matrix genes, VEGF signaling and associates with terms such as “cardiovascular development.” This is consistent with the TopGO analysis presented online in Supplementary Fig. S4.