Fig. 4.

Upregulation of a second highly significant IPA gene network (IPA network score = 41) in response to endurance training in high responders (A), but not in low responders (B). Aerobic training was found to be associated with differential increases (>1.5 FC, dark gray boxes) and decreases (>1.4 FC, light gray boxes) in gene expression almost exclusively in the high responders to aerobic training. This network is regulated by NF-kB, TGF-β, IGF2 and insulin, includes a number of major histocompatibility complex (MHC) genes, and is associated with embryonic tissue development according to IPA.