Table 2.

A-317491 effect on baseline ventilatory and metabolic parameters in developing rats

Age, days	Drug	n	Weight, g	Temperature, °C	fR, breaths/min	Vt, ml/100 g	V̇e, ml · min−1 · 100 g−1	V̇o2, ml · min−1 · 100 g−1	V̇co2, ml · min−1 · 100 g−1	V̇e/V̇o2	V̇e/V̇co2
4	Vehicle	10	10.9 ± 1.1	33.7 ± 0.1	162 ± 3	1.23 ± 0.1	202 ± 13	5.2 ± 0.4	3.6 ± 0.2	44 ± 4	57 ± 5
	A-317491	5	9.2 ± 0.5	33.8 ± 0.4	132 ± 3*	0.70 ± 0.1*	95 ± 20*	2.2 ± 0.3*	1.5 ± 0.2*	41 ± 5	61 ± 6
7	Vehicle	6	17.5 ± 1.3	35.7 ± 0.3	164 ± 3	0.86 ± 0.1	149 ± 15	4.5 ± 0.3	3.2 ± 0.2	39 ± 6	49 ± 6
	A-317491	6	16.8 ± 1.2	34.7 ± 0.2	134 ± 7*	0.46 ± 0.1*	60 ± 8*	1.7 ± 0.2*	1.4 ± 0.1*	37 ± 5	42 ± 5
21	Vehicle	10	50.5 ± 1.7	36.7 ± 0.7	143 ± 2	0.82 ± 0.1	129 ± 5	3.7 ± 0.2	2.3 ± 0.1	34 ± 1	43 ± 10
	A-317491	6	47.4 ± 2.8	36.7 ± 0.1	105 ± 3*	0.66 ± 0.1*	69 ± 5*	2.1 ± 0.2*	1.4 ± 0.2*	35 ± 5	51 ± 7

Values are means ± SE; n, no. of rats. Body temperature (°C) was recorded orally (postnatal days 4 and 7) and rectally (postnatal day 21). Shown are f_R, Vt, V̇e, V̇o₂, V̇co₂, V̇e/V̇o₂, and V̇e/V̇co₂ after single intraperitoneal injection of vehicle (saline) or A-317491 (150 mg/kg) in 4-, 7-, and 21-day-old rats.

^*P < 0.05 vs. vehicle.