Figure 1.

Antiviral, diabetogenic CTL in the RIP-LCMV.GP diabetes model as visualized by intravital two-photon imaging in the pancreas. The technique is described in Coppieters et al. (2010). Briefly, purified and labeled P14 TCR-transgenic CTL is transferred to RIP-LCMV.GP hosts, followed by infection with LCMV. As such, the kinetics of the diabetogenic CTL response can be dynamically visualized in the pancreas. (Magenta) Insulin-producing β cells, (green) CTL, (red) vasculature after dye injection.