Table 3.
Parameters | Saline | Til-HCO-SLN | Blank HCO-SLN | Tilmicosin (n = 5) | |
---|---|---|---|---|---|
AST (U/L) | H | 147.78 ± 37.78 | 157.20 ± 34.95 | 150.20 ± 24.15 | |
L | 152.14 ± 18.77 | 143.29 ± 19.79 | 150.00 ± 16.12 | 171.00 ± 17.15 | |
ALT (U/L) | H | 44.56 ± 17.37 | 37.11 ± 9.18 | 41.00 ± 10.79 | |
L | 42.86 ± 8.28 | 47.14 ± 11.05 | 49.57 ± 7.28 | 50.75 ± 0.96 | |
ALT/AST | H | 0.30 ± 0.04 | 0.26 ± 0.06 | 0.27 ± 0.05 | |
L | 0.29 ± 0.06 | 0.33 ± 0.07 | 0.33 ± 0.05 | 0.30 ± 0.03 | |
ALP (U/L) | H | 136.44 ± 34.46 | 150.60 ± 19.57 | 140.29 ± 21.47 | |
L | 121.71 ± 22.89 | 111.14 ± 19.30 | 121.50 ± 27.77 | 135.25 ± 17.00 | |
TBIL (umol/L) | H | 2.56 ± 1.43 | 1.86 ± 0.94 | 1.81 ± 0.89 | |
L | 0.90 ± 0.42 | 0.74 ± 0.35 | 1.09 ± 0.41 | 1.38 ± 1.05 | |
CHOL (mmol/L) | H | 3.86 ± 0.48 | 4.21 ± 0.89 | 3.81 ± 0.92 | |
L | 3.53 ± 0.54 | 3.54 ± 0.62 | 3.69 ± 0.74 | 3.67 ± 0.44 | |
CREA (umol/L) | H | 11.60 ± 3.27 | 13.13 ± 1.73 | 11.80 ± 2.53 | |
L | 18.29 ± 4.57 | 18.00 ± 3.42 | 18.25 ± 1.91 | 17.25 ± 0.96 | |
BUN (mmol/L) | H | 7.53 ± 1.96 | 7.00 ± 1.12 | 6.72 ± 1.11 | |
L | 8.59 ± 1.54 | 9.54 ± 1.48 | 9.47 ± 1.79 | 9.70 ± 0.58 | |
TP (g/L) | H | 60.90 ± 2.77 | 60.80 ± 2.57 | 56.00 ± 3.02b | |
L | 61.31 ± 3.57 | 59.37 ± 1.86 | 60.69 ± 2.81 | 61.03 ± 2.16 | |
ALB (g/L) | H | 41.49 ± 1.60 | 40.44 ± 2.13 | 38.34 ± 1.26b | |
L | 38.09 ± 4.89 | 37.06 ± 5.21 | 36.56 ± 3.35 | 38.90 ± 4.22 | |
GLB (g/L) | H | 19.41 ± 1.45 | 20.36 ± 1.31 | 17.66 ± 2.01b | |
L | 23.21 ± 2.18 | 22.31 ± 3.94 | 24.13 ± 2.70 | 22.13 ± 2.81 | |
ALB/GLB | H | 2.14 ± 0.12 | 1.99 ± 0.16a | 2.19 ± 0.19 | |
L | 1.71 ± 0.34 | 1.84 ± 0.46 | 1.74 ± 0.31 | 1.80 ± 0.41 | |
GLU (mmol/L) | H | 6.07 ± 1.68 | 5.98 ± 1.27 | 6.33 ± 1.45 | |
L | 5.18 ± 1.78 | 5.02 ± 1.51 | 4.95 ± 1.18 | 5.78 ± 0.57 |
a Significant difference between Til-HCO-SLN and saline treated mice, p < 0.05.
b Significant difference between blank HCO-SLN and saline treated mice, p < 0.05.
Abbreviations: H: high dose; L: low dose; AST: aspartate aminotransferase; ALT: serum alanine aminotransferas; ALP: alkaline phosphatase; TBIL: total bilirubin; CHOL: cholesterol esters; CREA: creatinine; BUN: blood urea nitrogen; TP: total proteins; ALB: albumin; GLB: globulin; GLU: glucose.