Table 4.
Parameters | Saline | Til-HCO-SLN | Blank HCO-SLN | Tilmicosin (n = 5) | |
---|---|---|---|---|---|
WBC (109/L) | H | 5.51 ± 1.55 | 5.52 ± 1.68 | 4.95 ± 1.39 | |
L | 5.89 ± 1.80 | 5.05 ± 1.06 | 5.22 ± 0.93 | 5.16 ± 0.78 | |
RBC | H | 8.56 ± 1.30 | 7.58 ± 1.40 | 7.07 ± 1.14b | |
(1012/L) | L | 9.64 ± 0.79 | 9.58 ± 0.96 | 9.63 ± 0.56 | 9.08 ± 0.69 |
HCT (L/L) | H | 0.44 ± 0.05 | 0.40 ± 0.03 | 0.36 ± 0.05b | |
L | 0.59 ± 0.09 | 0.61 ± 0.07 | 0.58 ± 0.06 | 0.57 ± 0.07 | |
MCV (fL) | H | 51.01 ± 2.69 | 51.06 ± 2.10 | 51.72 ± 4.05 | |
L | 60.37 ± 5.74 | 63.18 ± 4.22 | 60.63 ± 5.34 | 62.47 ± 4.76 | |
HGB (g/L) | H | 141.44 ± 10.48 | 129.89 ± 10.25 | 119.43 ± 15.80b | |
L | 153.63 ± 9.97 | 155.00 ± 12.00 | 153.38 ± 6.02 | 147.80 ± 4.21 | |
MCH (pg) | H | 16.84 ± 2.33 | 16.44 ± 1.67 | 16.99 ± 1.77 | |
L | 15.96 ± 0.46 | 16.21 ± 0.57 | 15.94 ± 0.54 | 16.30 ± 0.80 | |
MCHC (g/L) | H | 329.33 ± 32.11 | 320.70 ± 22.14 | 328.00 ± 19.47 | |
L | 266.88 ± 29.78 | 257.13 ± 15.75 | 264.50 ± 23.68 | 262.40 ± 27.93 | |
PLT (109/L) | H | 873.89 ± 139.28 | 812.29 ± 157.35 | 802.00 ± 154.55 | |
L | 971.13 ± 145.25 | 967.63 ± 171.96 | 925.88 ± 219.88 | 972.60 ± 233.96 | |
MPV (fL) | H | 6.74 ± 1.78 | 6.50 ± 1.14 | 6.25 ± 1.16 | |
L | 5.43 ± 0.29 | 5.28 ± 0.21 | 5.25 ± 0.22 | 5.32 ± 0.38 | |
PCT (L/L) | H | 0.57 ± 0.21 | 0.47 ± 0.10 | 0.40 ± 0.11b | |
L | 0.53 ± 0.07 | 0.57 ± 0.09 | 0.55 ± 0.11 | 0.56 ± 0.06 | |
RDW (fL) | H | 11.83 ± 3.81 | 11.70 ± 2.28 | 11.75 ± 1.74 | |
L | 17.21 ± 0.79 | 18.00 ± 1.90 | 17.47 ± 2.02 | 17.72 ± 1.37 | |
NEU (%) | H | 14.75 ± 2.02 | 15.70 ± 2.22 | 17.83 ± 1.50 | |
L | 15.96 ± 5.04 | 20.06 ± 5.33 | 18.99 ± 3.12 | 20.44 ± 5.95 | |
LYM (%) | H | 84.25 ± 2.78 | 81.64 ± 3.94 | 80.63 ± 1.32 | |
L | 80.71 ± 5.68 | 74.93 ± 5.84 | 76.43 ± 4.69 | 76.88 ± 6.40 | |
MON (%) | H | 0.85 ± 0.07 | 1.73 ± 1.13 | 1.30 ± 0.36 | |
L | 2.84 ± 1.03 | 4.30 ± 1.77 | 3.85 ± 1.73 | 2.24 ± 1.18 | |
EOS (%) | H | 0.20 ± 0.08 | 0.23 ± 0.19 | 0.15 ± 0.10 | |
L | 0.26 ± 0.17 | 0.40 ± 0.13 | 0.33 ± 0.10 | 0.16 ± 0.11 | |
BAS (%) | H | 0.17 ± 0.10 | 0.24 ± 0.14 | 0.18 ± 0.16 | |
L | 0.23 ± 0.07 | 0.31 ± 0.22 | 0.41 ± 0.29 | 0.28 ± 0.15 |
a Significant difference between Til-HCO-SLN and saline treated mice, p < 0.05.
b Significant difference between blank HCO-SLN and saline treated mice, p < 0.05.
Abbreviations: H: high dose; L: low dose; WBC: white blood cells; RBC: red blood cells; HCT: haematocrit; MCV: mean corpuscular volume; HGB: hemoglobin; MCH: mean corpuscular haemoglobin; MCHC: mean corpuscular haemoglobin concentration; PLT: blood platelet; MPV: mean platelet volume; PCT: plateletcrit; RDW: red cell distribution width; NEU: neutrophils; LYM: lymphocytes; MON: monocytes; EOS: eosinophils; BAS: basophils.