Table 1. Clinicopathological, Karyometric, and Immunohistochemical Characteristics of Breast Cancer Cases and by ER and PR status.
| All | ER+/PR+ | ER−&PR− | ||
| (N = 645) | (N = 504) | (N = 141) | PER−&PR− vs. ER+/PR+ 1 | |
| Age at diagnosis (years), ±SD4 | 59±14 | 59±14 | 59±16 | 0.67 |
| Median±interquartile range | 60±21 | 60±21 | 57±24 | 0.66 |
| <50, n (%) | 467 (72%) | 366 (73%) | 101 (72%) | 0.83 |
| ≥50, n (%) | 178 (28%) | 138 (27%) | 40 (28%) | |
| Tumor size (cm), ±SD4 | 3.5±3.2 | 3.4±3.3 | 3.6±2.5 | 0.48 |
| Histological type 2, n (%) | <0.001 | |||
| Invasive ductal carcinoma | 531 (83%) | 420 (84%) | 111 (79%) | |
| Invasive lobular carcinoma | 57 (9%) | 49 (10%) | 8 (6%) | |
| Invasive medullary carcinoma | 21 (3%) | 5 (1%) | 16 (11%) | |
| Other | 34 (5%) | 29 (6%) | 5 (4%) | |
| Axillary lymph node metastases 2, n (%) | 338 (53%) | 274 (55%) | 64 (45%) | 0.041 |
| Microscopic grade 2, n (%) | <0.001 | |||
| Grade I | 117 (22%) | 110 (25%) | 7 (7%) | |
| Grade II | 305 (57%) | 263 (61%) | 42 (39%) | |
| Grade III | 117 (22%) | 59 (14%) | 58 (54%) | |
| S-phase fraction, n (%) | <0.001 | |||
| Low (≤5%) | 252 (39%) | 224 (44%) | 28 (20%) | |
| Moderate (>5–10%) | 248 (38%) | 190 (38%) | 58 (41%) | |
| High (>10%) | 145 (22%) | 90 (18%) | 55 (39%) | |
| MIB-1 2, n (%) | <0.001 | |||
| Low (≤17%) | 155 (30%) | 148 (37%) | 7 (6%) | |
| Moderate (18–34%) | 201 (38%) | 167 (42%) | 34 (28%) | |
| High (≥35%) | 168 (32%) | 86 (21%) | 82 (67%) | |
| P53 expression 2, n (%) | 0.009 | |||
| Negative | 257 (62%) | 207 (66%) | 50 (51%) | |
| Positive | 158 (38%) | 109 (34%) | 49 (49%) | |
| Ploidy 2, n (%) | 0.049 | |||
| Diploid & near-diploid | 199 (31%) | 167 (33%) | 32 (23%) | |
| Hyperploid | 411 (64%) | 309 (61%) | 102 (72%) | |
| Hypoploid | 34 (5%) | 27 (5%) | 7 (5%) | |
| Nuclear area 3 (µm2), ±SD4 | 104±46 | 99±42 | 121±56 | 0.001 |
| Perimeter 3(µm), ±SD4 | 70±14 | 68±13 | 75±17 | 0.002 |
| Spherical 3 (%), ±SD4 | 59±15 | 60±14 | 55±17 | 0.014 |
| Oval 3 (%), ±SD4 | 31±7 | 31±7 | 31±8 | 0.96 |
| Cylindrical 3 (%), ±SD4 | 11±18 | 10±19 | 14±14 | 0.035 |
1
Ps for categorical variables were estimated from χ2 tests. P for the comparison of median ages was esimated from Wilcoxon Rank-Sum test and Ps for other continuous variables were estimated from t-tests.
2
Histology, lymph node metastasis, grade, MIB1, P53 expression and DNA ploidy index, were unknown for 2, 7, 106, 121, 230 and 1 cases, respectively.
3
Data on nuclear are, perimeter and DNA shape were available for only 353 cases.
4
Mean ±standard deviation.