Table 2. Clinicopathological, karyometric, and immunohistochemical characteristics of breast cancer by family history.
| No family history | Family history | ||
| (n = 520) | (n = 125) | P 1 | |
| Age at diagnosis (years), ±SD4 | 60±14 | 54±14 | <0.001 |
| Median±interquartile range | 61±21 | 50±23 | <0.001 |
| <50, n (%) | 117 (22%) | 61 (49%) | <0.001 |
| ≥50, n (%) | 403 (78%) | 64 (51%) | |
| Tumor size (cm), ±SD4 | 3.6±3.4 | 3.0±1.6 | 0.007 |
| Histological type 2, n (%) | 0.082 | ||
| Invasive ductal carcinoma | 421 (81%) | 110 (89%) | |
| Invasive lobular carcinoma | 50 (10%) | 7 (6%) | |
| Invasive medullary carcinoma | 16 (3%) | 5 (4%) | |
| Other | 32 (6%) | 2 (2%) | |
| Axillary lymph node metastases 2, n (%) | 270 (53%) | 68 (54%) | 0.76 |
| Microscopic grade 2, n (%) | <0.13 | ||
| Grade I | 99 (23%) | 18 (16%) | |
| Grade II | 232 (54%) | 73(65%) | |
| Grade III | 95 (22%) | 22 (19%) | |
| S-phase fraction, n (%) | 0.30 | ||
| Low (≤5%) | 210 (40%) | 42 (34%) | |
| Moderate (>5–10%) | 193 (37%) | 55 (44%) | |
| High (>10%) | 117 (23%) | 28 (22%) | |
| MIB-1 2, n (%) | 0.22 | ||
| Low (≤17%) | 128 (31%) | 27 (26%) | |
| Moderate (18–34%) | 164 (39%) | 37 (35%) | |
| High (≥35%) | 127 (30%) | 41 (39%) | |
| Ploidy 2, n (%) | 0.78 | ||
| Diploid & near-diploid | 160 (31%) | 39 (31%) | |
| Hyperploid | 330 (64%) | 81 (65%) | |
| Hypoploid | 29 (6%) | 5 (4%) | |
| P53 expression 2, n (%) | 0.089 | ||
| Negative | 203 (60%) | 54 (71%) | |
| Positive | 136 (40%) | 22 (29%) | |
| Nuclear area 3 (µm2), ±SD4 | 105±46 | 96±44 | 0.18 |
| Perimeter 3(µm), ±SD4 | 70±15 | 67±13 | 0.11 |
| Spherical 3 (%), ±SD4 | 58±15 | 63±14 | 0.032 |
| Oval 3 (%), ±SD4 | 31±7 | 30±7 | 0.37 |
| Cylindrical 3 (%), ±SD4 | 12±19 | 7±9 | 0.005 |
1
Ps for categorical variables were estimated from χ2 tests. P for the comparison of median ages was esimated from Wilcoxon Rank-Sum test and Ps for other continuous variables were estimated from t-tests.
2
Histology, lymph node metastasis, grade, MIB1, P53 expression and DNA ploidy index were unknown for 11, 48, 2, 7, 106, 121, 230 and 1 cases, respectively.
3
Data on nuclear are, perimeter and DNA shape were available for only 353 cases.
4
Mean ±standard deviation.