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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: J Neurochem. 2011 Nov 28;120(3):440–452. doi: 10.1111/j.1471-4159.2011.07576.x

Figure 3. CREB-promoted transcriptional activity is inhibited by oligomeric αSyn in both basal and AC/PKA-stimulated conditions in SY5Y cells.

Figure 3

Release of the reported gene product SEAP in SY5Y cells transiently transfected with the CREB-sensitive CRE-SEAP construct and treated for 3 h with oligomeric or fibrillary αSyn (2 µM) in the presence or absence of the AC/PKA activator forskolin (10 µM). n=6 replicates per group; *: p<0.01 vs. control cells (ANOVA).