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. Author manuscript; available in PMC: 2013 Jan 15.
Published in final edited form as: Free Radic Biol Med. 2011 Nov 3;52(2):303–313. doi: 10.1016/j.freeradbiomed.2011.10.488

Fig. 7. Rac1 participates in rotenone-induced PHOX activation.

Fig. 7

(A) In the cell-free system reconstituted from membrane and cytosolic fractions of RAW 264.7 cells, rotenone-induced superoxide production was blocked by DPI. GTPγS significantly increased rotenone-elicited superoxide production; such superoxide production was also prevented by DPI. (B) Rac1 inhibitor NSC 23766 (100 µM) significantly attenuated rotenone-induced extracellular superoxide release in primary microglia.