Table 4.
Correlation of protein biomarker concentrations from acute KD subjects with demographic, echocardiographic, and laboratory data.
| Biomarker | sST2 (ng/mL) |
cTnI (ng/mL) |
Age at Onset (yrs) |
Illness Day |
CRP (mg/dL) |
ALT (IU/L) |
GGT (IU/L) |
MV A |
MV E:A |
DT (ms) |
DTI E:A |
RCA/LAD Zworst |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| NT- proBNP |
−0.50† | 0.27 | −0.45* | −0.43* | 0.39* | 0.33 | 0.27 | 0.41 | −0.44 | −0.74† | NS | 0.41* |
| sST2 | 1.0† | NS | NS | −0.52† | NS | 0.54† | 0.58† | NS | NS | −0.53* | NS | NS |
Values represent Spearman rank correlation coefficient, r2. All values significant at P ≤ 0.05, unless otherwise noted: P < 0.005,
P < 0.0001. NS= not significant. MV A, MV E:A, and DT measured in only 28 patients. cTnI did not significantly correlate with measures of systolic or diastolic function, or clinical laboratory data. NT-proBNP = N-terminal pro-B-type natriuretic peptide; sST2 = soluble ST2; cTnI = cardiac troponin I; Illness day = first day of fever is Day 1; CRP = C-reactive protein; ALT= alanine amino transferase; GGT = γ-glutamyl transferase; MV A = mitral valve A-wave; MV E:A = ratio of mitral valve E-wave and A-wave; DT = deceleration time; DTI = Doppler tissue imaging; RCA/LAD Zworst= worst Z-score of either right coronary artery or left anterior descending coronary artery measured at 3 time points.