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. Author manuscript; available in PMC: 2013 Jan 15.
Published in final edited form as: J Immunol. 2011 Dec 19;188(2):774–780. doi: 10.4049/jimmunol.1101383

Fig. 6. Model on the role of NO in the induction of inflammatory cytokines.

Fig. 6

Phagocytosis of GBS activates NFκB and induces transcriptional activation of iNOS in a MYD88 dependent fashion. NO is critical for the acidification of the phagosome and thereby modifies nucleic acids of internalized GBS. NO-modified single stranded GBS RNA eventually results in further transcriptional activation of cytokine genes.